Royal Air Force Typhoon jets have operated alongside French warplanes in a coordinated attack targeting an subterranean weapons facility in Syria used by the IS group, per a report from the UK's MoD.
The location, identified by reconnaissance, was believed to be housing weapons and explosive materials, the statement said, and was positioned in hills just north of the ancient city of Palmyra in Syria's central region.
"The RAF jets used precision-guided Paveway IV munitions to hit a several access tunnels leading to the site... initial indications indicate the target was engaged successfully," the ministry announced.
There was no sign of any civilian casualties in the operation on Saturday evening and all the aircraft returned to base without incident, the MoD added.
The British jets were supported by a Voyager tanker plane.
The Islamic State group - alternatively referred to as ISIS - enforced extremist governance over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This operation demonstrates British leadership, and commitment to operate in unison with our partners, to eradicate any re-emergence of Daesh and their violent and radical beliefs in the area," the British Defence Secretary the minister remarked.
British military aircraft have carried out surveillance missions over Syrian airspace to "deter any efforts to regroup" of IS subsequent to its routing at the Baghuz confrontation in 2019, the ministry said.
"I extend gratitude to all the members of our armed forces involved in this strike for their professionalism and their bravery," he said. "They were part of thousands of UK service members deployed over the festive period. This operation, to eliminate militants who threaten our safety, demonstrates how UK forces are always on standby, all year round, ensuring Britain's security at home and influential overseas."
In December, the US military conducted what it described as a "massive strike" on Islamic State objectives in the country, after an ambush killed two US troops and a civilian linguist in the Palmyra area.
The United Nations says Daesh still maintains an estimated 5,000 to 7,000 combatants in both countries.